with Midtjylland, after the France striker picked up a hamstring injury in the warm-up.
Martial had been down to start the match at Old Trafford, with the Red Devils looking to overturn a 2-1 deficit from the first leg in Denmark.
But Louis van Gaal's side have now been presented with another obstacle as young striker Marcus Rashford comes in to make his debut for the club.
The striker receives his first senior outing in the crucial clash having only featured for the club's under-18 and under-19 sides before, never previously turning out for the under-21s.
Van Gaal had already been forced to make several awkward selection choices for Thursday's starting XI, fielding Michael Carrick and Daley Blind as a makeshift centre-back pairing.
SOURCE:GOAL.COM
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